Technological progress as along a tech tree; cheap energy as the next frontier; labor isn’t free; don’t optimize things non-mission-critical things that you can outsource; there’s no such thing as infinite resources; everything is an optimization problem; people can’t perceive reality, just your marketing of it; fundraising is a marketing problem; delegation is not a magic wand; leadership is marketing and decision making; startups have to solve their problems, not just get funded; the easiest way to market something is to be telling the truth; my vague discomfort with Davide’s priorities; the dangers of getting funding through sheer marketing (via Theranos); Holmes had to lie, or she’d get shut down; make sure you’re actually right, instead of getting a vision funded through brute force; blindly believing something doesn’t make it true; first lay out a path forward, then make sure it will work; will perfectly simulating a cell cure aging?; jumping dozens of orders of magnitude fundamentally changes the problem; Amazon is basically just a scaling problem; software complexity does not scale linearly; we can’t “train” a cell model because we don’t know anything about a cell for sure; accuracy of models depends on calibration; results of models still need to be tested in base reality; it is critically important that leaders and modelers know what they’re talking about; how do you know when you know enough; “origins of life” simulation wouldn’t replicate historical evolution; overview existing research on the origins of life (from Mattea, a biologist); evolution is random, so you can’t simulate it forwards and get the exact life we have today; if you constrain an evolutionary simulation to have a certain result, it’s no longer random or accurate; the history of science is realizing that our models are crap; you can’t find novel ground truths through models; I haven’t made a high school because I don’t have an answer yet; sometimes you should start before you have a plan, because it’s hard to validate a plan before you start; always optimize for simplicity; I’m bad at optimizing for simplicity; always keep the end in mind, and look for easy hacks; always be doubting your premises; if you can simulate a human, there’s a ton of non-aging potential; the biggest value-add to fixing big problems is often unsexy; unhelpful fame and glory vs anonymous bigger impact; results count, not labor; my failure to launch a high school; we live at 20-30% overall efficiency; how can you work at 90% of potential?; fully-committed failure is scary; quantifying wasted time.

Check Davide out: https://daviderad.com

Check Mattea out: https://personal.website/matteaholtcolberg